But at least it's over for them.
Edwards suffered a high ankle sprain in Sunday's 17-10 loss to the New England Patriots at Ralph Wilson Stadium. An NFL source told ESPN.com's Tim Graham that Edwards was done for the season.
In addition, the Bills placed McGee on injured reserve with a rotator cuff injury that will end his season, requiring surgery this week, a person familiar with the pending procedure confirmed to Graham.
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Edwards, who lost his job as the starter a month ago, was given another shot in the fourth quarter when interim coach Perry Fewell pulled an ineffective Ryan Fitzpatrick.
Edwards lasted four plays, getting sacked twice. He had trouble getting to his feet before hobbling off the field.
McGee's operation is tentatively scheduled for Wednesday, according to the source. McGee was hurt early in the third quarter Sunday, when he attempted to break up a pass to Randy Moss.
Leading with his right shoulder, McGee hit a leaping Moss in the hip as the receiver hung on for a 16-yard catch.
The Bills (5-9), who will miss the playoffs for a 10th straight season, play at Atlanta (7-7) on Sunday. Buffalo already has 15 players on injured reserve, including six who opened the year as starters.
The Buffalo News first reported Tuesday that McGee will have surgery.
Edwards' injury ends a tumultuous season for the third-year quarterback from Stanford, promoted by the Bills as their quarterback of the future his rookie season, when they stripped J.P. Losman of the job.
Edwards seemed to justify the move last year, when he helped the Bills bolt to a 5-1 start. But they fell apart and didn't make the playoffs.
He became a pariah among Bills fans for a never-ending series of injuries and an unwillingness to throw downfield. He was saddled with the nickname Captain Checkdown.
One of Fewell's first moves when taking over for the fired Dick Jauron was to replace Edwards with Fitzpatrick.
Edwards' final stat line for the year: seven starts, 60.1 completion percentage for 1,169 yards, six touchdowns and seven interceptions with a 73.8 passer rating.
McGee had been hampered by injuries all year. He played the first half of the season despite a torn ligament in his right knee, which he had repaired by surgery during the team's bye week in early November.
He returned to the lineup after missing three games.
McGee is a seven-year veteran, who signed a four-year contract extension in September.
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