Philadelphia (4-2) hosts New York (5-2) with first place in the NFC East at stake.
Westbrook has only 197 yards rushing this season. He didn't practice all week after he was knocked unconscious in the Eagles' 27-17 win over Washington on Monday night when he took a knee to his head.
Eagles rookie running back LeSean McCoy was expected to make his second start in Westbrook's place.
The second-round draft pick from Pitt started in Week 3 against Kansas City and gained 84 yards on 20 carries.
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Newly signed P.J. Hill, who was on the New Orleans practice squad, might also see some time.
Other notable inactives for the Eagles are safety Macho Harris (ankle), receiver Kevin Curtis (knee) and defensive end Victor Abiamiri (knee).
Giants cornerback Aaron Ross (hamstring) and receiver Mario Manningham (shoulder) were among their inactives.
Manningham hurt his left shoulder on the last play of practice Thursday. He was held out of the team's final workout. He has started six of seven games this season, catching 28 passes for 439 yards and four touchdowns.
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