Detroit coach Rod Marinelli said Monday that Orlovsky would make his second straight start in part because Daunte Culpepper is questionable because of a shoulder injury.
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Watch highlights from the Indianapolis Colts' 31-21 win over the Detroit Lions.
Detroit (0-14) hosts the New Orleans Saints as a 6-point underdog in its home finale, hoping to avoid being the NFL's first 0-15 team, then closes the season at Green Bay.
Orlovsky was 23-of-34 for 233 yards with a touchdown in a 31-21 loss Sunday at Indianapolis. He tied the game early in the fourth quarter with a 2-point conversion after leading a 13-play, 91-yard drive.
Culpepper threw four TDs and six interceptions over five starts before he hurt his shoulder Dec. 7 against Minnesota.
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