With all but three precincts reporting, the Republican had 80 percent of the vote to Democrat Wesley Burbage's 20 percent.
Wyche promised better roads, improved schools and more jobs.
The Atlanta native recently moved to the county where his wife was born. He played quarterback at nearby Furman University in Greenville.
In 1984, Wyche took over at Cincinnati where he went 61-66 in eight seasons. The Bengals won the AFC Championship in 1988 before losing the Super Bowl to the San Francisco 49ers on Joe Montana's touchdown pass in the final minute.
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