Lloyd has been hobbled by a knee injury while Manning has a pulled hamstring.
Starting cornerbacks Nathan Vasher (right wrist) and Charles Tillman (left shoulder) are questionable, as is backup cornerback Trumaine McBride (left shoulder) and linebacker Nick Roach (shoulder).
Vasher has missed the past two games, and Chicago's short-handed secondary took a few more hits last week against Atlanta. McBride and Tillman went down in the second quarter, and Manning, the Bears' nickel back, injured his hamstring in the third.
Lloyd was hurt against Philadelphia on Sept. 28 and will miss his third straight game.
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