Smith has a foot injury and Cox was benched in the second half of a season-opening win against Denver. Second-year pro Courtney Greene is to make his first career start, in place of Smith.
Cox started every game last season as a rookie, but struggled in training camp and the preseason. He was playing through a foot injury, but his struggles continued in the opener against Denver. He got beat several times and was benched in favor of David Jones in the second half.
Jones is to start in Cox's place.
Chargers inside linebacker Stephen Cooper was inactive with a knee injury.
Copyright 2010 by The Associated Press
Sources: Vincent Jackson, Marcus McNeill of San Diego Chargers to hold outAlbiol suffers injury blow
